Journal of Fluorine Chemistry

Reductive modification of difluoromethylene moiety in pentafluoropropionyl group

Y Nakamura, Y Ozeki, K Uneyama

Index: Nakamura, Yutaka; Ozeki, Yuu; Uneyama, Kenji Journal of Fluorine Chemistry, 2008 , vol. 129, # 4 p. 274 - 279

Full Text: HTML

Citation Number: 8

Abstract

The reductive Mg-promoted defluorinative-silylation of 2, 2, 3, 3, 3- pentafluoropropiophenone readily produces the α-trifluoromethyl enol silyl ether, which then react with electrophiles to give a variety of 2-substituted-3, 3, 3-trifluoropropiophenones in excellent yields. The same protocol is applicable for the preparation of enol silyl ether of 3, 3, 3-trifluoropropiophenone. Fluoride ion catalyzed 1, 2-desilylative-defluorination of 2, 3, 3, ...