Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons

D Makhey, B Gatto, C Yu, A Liu, LF Liu…

Index: Makhey, Darshan; Gatto, Barbara; Yu, Chiang; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 6 p. 781 - 791

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Citation Number: 96

Abstract

DNA topoisomerases are nuclear enzymes responsible for modifying the topological state of DNA. The development of agents capable of poisoning topoisomerases has proved to be an attractive approach in the search for novel cancer chemotherapeutics. Coralyne, an antileukemic alkaloid, has appreciable structural similarity to the potent topoisomerase I and II poison, nitidine. Analogues of coralyne were synthesized and evaluated for their activity ...