Novel Broad-Spectrum Anthelmintics. Tetramisole1 and Related Derivatives of 6-Arylimidazo [2, 1-b] thiazole

AHM Raeymaekers, FTN Allewijn…

Index: Raeymaekers,A.H.M. et al. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 545 - 551

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Citation Number: 137

Abstract

In a critical screeiiitig test in chickens, P-acetylimino-3-[2-hydrosy-2-(2-thienyl) ethyl] thiazoline (IT-, thiazothienol) was found to be active against, heterakids, ascarids, aiid capillarids. IT'was also active against various nematodes in sheep, but not in rat, s or in mice. In chickens and in sheep, biit not in mice or in rats, IT undergoes met, abolic ring closure to 5, 6-dih~-dro-6-(2-thieiiyl) imidazo [2, 1-b] thiazole (TII, thiazot, hielite), which is ...