Journal of heterocyclic chemistry

Synthesis and reactions of 6??methylsulfanyl??2, 4??dithioxo??1, 2, 3, 4??tetrahydropyrimidin??5??carbonitrile

D Briel, T Franz, B Dobner

Index: Briel, Detlef; Franz, Tanja; Dobner, Bodo Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 863 - 868

Full Text: HTML

Citation Number: 13

Abstract

Abstract The synthesis of 6-methylsulfanyl-2, 4-dithioxo-1, 2, 3, 4-tetrahydropyrimidine-5- carbonitrile 4 is described. Compound 4 was reacted with various alkylants. The reaction with chloroacetic acid derivatives results in the formation of thieno [2, 3-d] pyrimidines 8. When methyl iodide was used 2, 4, 6-tris (methylsul-fanyl) pyrimidine-5-carbonitrile 5 was obtained. The substitution of the methylsulfanyl groups in compound 5 by several N- ...