Synthesis of potential dual-acting radiation sensitizer antineoplastic agents: 2, 2-dimethylphosphoraziridines containing 2-nitroimidazoles or other electron-affinic …

…, JA Dunn, TA Piscitelli, J Earle, WC Rose…

Index: Perlman, Michael E.; Dunn, Joseph A.; Piscitelli, Thomas A.; Earle, Julie; Rose, William C.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1400 - 1407

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Citation Number: 10

Abstract

In view of the in vivo demonstrated radiation-potentiating activities of several previously studied 2, 2-dimethylphosphoraziridines, six new compounds incorporating the bis (2, 2- dimethyl-1-aziridinyl) phosphinyl moiety, together with an electron-affiiic group such as 2- nitroimidazole or nitrobenzyl, have been synthesized and tested (1) in vitro for ability to increase the effect of X-irradiation under hypoxic conditions on V-79 Chinese hamster ...