Die Addition von Nucleophilen an Alkinderivate mit Push??pull??Gruppen

A Niederhauser, A Frey…

Index: Niederhauser,A. et al. Helvetica Chimica Acta, 1973 , vol. 56, p. 944 - 958

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Citation Number: 20

Abstract

Abstract The preparative aspects of the addition of nucleophiles to alkyne-derivatives having both push-and pull-groups (1) are discussed: The addition of primary and secondary amines as well of aliphatic alcohols to the alkyne-derivatives 1 in most cases predominantly yields the Michael-adducts 2–10. The importance of a side-reaction consisting in an addition of amines to C (2) of the alkyne-derivatives 1 increases in the series 1c≪ 1b< 1a and is ...