Sugar??Assisted Kinetic Resolution of Amino Acids and Amplification of Enantiomeric Excess of Organic Molecules

…, Y Xu, I Ibrahem, W Zou, M Engqvist

Index: Cordova, Armando; Sunden, Henrik; Xu, Yongmei; Ibrahem, Ismail; Zou, Weibiao; Engqvist, Magnus Chemistry - A European Journal, 2006 , vol. 12, # 21 p. 5446 - 5451

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Citation Number: 23

Abstract

Abstract The origins of biological homochirality have intrigued researchers since Pasteur's discovery of the optical activity of biomolecules. Herein, we propose and demonstrate a novel alternative for the evolution of homochirality that is not based on autocatalysis and forges a direct relationship between the chirality of sugars and amino acids. This process provides a mechanism in which a racemic mixture of an amino acid can catalyze the ...