Total synthesis and stereochemistry of uncialamycin

…, JS Chen, JJ Crawford, L Pasunoori

Index: Nicolaou; Zhang, Hongjun; Chen, Jason S.; Crawford, James J.; Pasunoori, Laxman Angewandte Chemie - International Edition, 2007 , vol. 46, # 25 p. 4704 - 4707

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Citation Number: 35

Abstract

Uncialamycin was isolated from an unreported strain of Streptomycete, related to Streptomyces cyanogenus, and exhibits potent plasmid DNA cleavage and phenomenal in vitro activity against Staphylococcus aureus (MIC 0.0000064 μg mLÀ1), as well as activity against Escherichia coli (MIC 0.002 μg mLÀ1) and Burkholderia cepacia (MIC 0.001 μg mLÀ1).[1] The scarcity of uncialamycin (only 300 μg were isolated) limited both the ...