Synlett

Total synthesis of altenusin and alterlactone

J Cudaj, J Podlech

Index: Cudaj, Judith; Podlech, Joachim Synlett, 2012 , # 3 p. 371 - 374

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Citation Number: 4

Abstract

Abstract The resorcylic lactone alterlactone, a mycotoxin produced by alternaria sp., was synthesized for the first time. The total synthesis was achieved in nine steps with 69% yield starting with acetal-protected phloroglucinic acid and 6-bromopiperonal, where the longest linear sequence consists of five steps. Key step is a Suzuki coupling used for the construction of the central biaryl bond. When the final deprotection with cleavage of benzyl ...