Organic letters

Palladium-Catalyzed Synthesis of 2-(Aminomethyl) indoles from Ethyl 3-(o-Trifluoroacetamidophenyl)-1-propargyl Carbonate

I Ambrogio, S Cacchi, G Fabrizi

Index: Ambrogio, Ilaria; Cacchi, Sandro; Fabrizi, Giancarlo Organic Letters, 2006 , vol. 8, # 10 p. 2083 - 2086

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Citation Number: 51

Abstract

The palladium-catalyzed reaction of ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate with piperazines in the presence of Pd (PPh3) 4 in THF at 80° C affords 2- (piperazin-1-ylmethyl) indoles in excellent yields. Good to excellent yields are also obtained with other secondary amines.