Bioorganic & medicinal chemistry letters

Novel phosphinic and phosphonic acid analogues of the anticonvulsant valproic acid

J Kehler, HI Hansen, C Sanchez

Index: Kehler, Jan; Hansen, Henrik I.; Sanchez, Connie Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 22 p. 2547 - 2548

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Citation Number: 11

Abstract

1-Propylbutylphosphinic acid 2,(1-propylbutyl) methylphosphinic acid 3 and 1- propylbutylphosphonic acid 4 have been synthesized as bioisosteres of the corresponding carboxylic acid valproate 1, which is a potent anticonvulsant. The novel phosphinic and phosphonic acids were tested for their anticonvulsant activity and were found to be inactive.