Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4, 5-diphenyl-2-oxazolyl)-5-oxazolyl] phenoxy] acetic acid

NA Meanwell, JL Romine, MJ Rosenfeld…

Index: Meanwell, Nicholas A.; Romine, Jeffrey L.; Rosenfeld, Michael J.; Martin, Scott W.; Trehan, Ashok K.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3884 - 3903

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Citation Number: 53

Abstract

In previous studies, we have described the discovery and structureactivity relationships associated with a series of prostacyclin (PGIz) mimetics that are structurally quite different to the endogenous prostanoid.'" This effort was initiated following the discovery that the triphenylated imidazole derivative octimibate acts as a partial agonist at the prostacyclin re~ eptor.~~~ This new class of PGIz mimetic, characterized by architectural simplicity and ...