… biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17α-hydroxylase/17, 20-lyase (P- …
S Ahmed, I Shahid, S Dhanani, CP Owen
Index: Ahmed, Sabbir; Shahid, Imran; Dhanani, Sachin; Owen, Caroline P. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 16 p. 4698 - 4701
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Citation Number: 9
Abstract
We report the synthesis and biochemical evaluation of a range of 4-sulfonated derivatives of 4-hydroxybenzyl imidazole which has been targetted against the two components of 17α- hydroxylase/17, 20-lyase (P-45017α), namely, 17α-hydroxylase (17α-OHase) and 17, 20- lyase (lyase). The results from the biochemical testing suggest that the compounds synthesised are highly potent inhibitors possessing excellent selectivity towards the lyase ...
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