Reactivity??Controlled Regioselectivity: A Regiospecific Synthesis of 1, 2??Disubstituted Benzimidazoles
X Deng, NS Mani
Index: Deng, Xiaohu; Mani, Neelakandha S. European Journal of Organic Chemistry, 2010 , # 4 p. 680 - 686
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Citation Number: 26
Abstract
Abstract We demonstrate exceptional levels of regioselectivity in the tandem amination reactions between 1, 2-differentiated dihaloarenes and N-substituted amidines. The regiochemical outcome of this CuI-catalyzed reaction is achieved through a combination of N 1/N 2 chemoselectivity on the amidine and reactivity-controlled X 1/X 2 chemoselectivity on the 1, 2-dihaloarene. This reaction proves to be fairly general for the regiospecific ...
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