Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity

NH Nam, YJ You, Y Kim, DH Hong, HM Kim…

Index: Nam, Nguyen-Hai; You, Young-Jae; Kim, Yong; Hong, Dong-Ho; Kim, Hwan-Mook; Ahn, Byung Zun Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1173 - 1176

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Citation Number: 34

Abstract

A series of 3-aryl-2-propenoates including cinnamates,(E)-methyl/ethyl 3-[2-(1, 4-dimethoxy- 5, 8-dione) naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1, 4-dihydroxy- 9, 10-dione) anthracenyl]-2-propenoates (9aa, 9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho-or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab ...

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