Metabolism of Aloesin and Related Compounds by Human Intestinal Bacteria: A Bacterial Cleavage of the C-Glucosyl Bound and the Subsequent Reduction of the …

…, M HATTORI, K KOBASHI, T NAMBA

Index: Che; Akao; Hattori; Kobashi; Namba Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 704 - 708

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Abstract

By anaerobic incubation with a bacterial mixture from human feces, aloesin (aloeresin B; 1) was converted to 2-acetonyl-7-hydroxy-5-methylchromone (aloesone; 3) and dl-7-hydroxy-2- (2'-hydroxypropyl)-5-methylchromone (aloesol; 4a+ 4b) through a cleavage of the C- glucosyl bond, followed by reduction of the acetonyl side chain. An analogous compound, aloeresin A (2), was converted to p-coumaric acid and aloesin (1), the latter being ...