Chemical and Pharmaceutical Bulletin

Titanium (IV) chloride-mediated ring cleavage and Michael addition of 3, 3-dialkylcyclobutanones and 3-[(trimethylsilyl) methyl]-cyclobutanones

R Okuno, J Matsuo, H Ishibashi

Index: Okuno, Ryosuke; Matsuo, Jun-Ichi; Ishibashi, Hiroyuki Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 6 p. 793 - 797

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Abstract

β′-Chloro and β′, γ′-unsaturated trichlorotitanium enolates, which were formed in situ by titanium (IV) chloride-mediated ring cleavage of 3, 3-dialkylcyclobutanones and 3- [(trimethylsilyl) methyl] cyclobutanones, reacted with enones to give Michael adducts with keeping a labile β′-chloro or β′, γ′-unsaturated group.