Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone

…, BN Singh, M Temciuc, S Nilsson, YL Li…

Index: Carlsson, Bo; Singh; Temciuc, Marcel; Nilsson, Stefan; Li, Yi-Lin; Mellin, Charlotta; Malm, Johan Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 623 - 630

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Citation Number: 105

Abstract

Recent developments in antiarrhythmic therapy have indicated that the best approach to pharmacologically controlling supraventricular arrhythmias and life-threatening ventricular tachyarrhythmias is by prolonging cardiac repolarization rather than by blocking conduction. In this context, amiodarone has emerged as the most potent compound, but its universal use has been limited by its toxicity profile. There are data to suggest that an important ...