Carboxylation and Esterification of Functionalized Arylcopper Reagents §

…, WL Juda, RH Kosakowski, B Ma, L Dong…

Index: Ebert, Greg W.; Juda, Wayne L.; Kosakowski, Robert H.; Ma, Bing; Dong, Liming; Cummings, Keith E.; Phelps, Mwita V. B.; Mostafa, Adel E.; Luo, Jianyuan Journal of Organic Chemistry, 2005 , vol. 70, # 11 p. 4314 - 4317

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Citation Number: 36

Abstract

Functionalized arylcopper reagents have been produced in good yields at 25° C from activated copper and the corresponding functionalized aryl iodides without the need of traditional organolithium or Grignard precursors. These organocopper compounds will undergo carboxylation with CO2 to form the corresponding copper benzoates. In turn, these salts can be acidified to produce the functionalized aryl acids or treated with appropriate ...