Direct Use of Esters in the Mukaiyama Aldol Reaction: A Powerful and Convenient Alternative to Aldehydes
Y Inamoto, Y Nishimoto, M Yasuda, A Baba
Index: Inamoto, Yoshihiro; Nishimoto, Yoshihiro; Yasuda, Makoto; Baba, Akio Organic Letters, 2012 , vol. 14, # 4 p. 1168 - 1171
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Citation Number: 14
Abstract
An indium triiodide catalyst promoted the direct transformation from esters to β- hydroxycarbonyl compounds using hydrosilanes and silyl enolates by a one-stage process. Various esters were applicable, and the high chemoselectivity of this system brings compatibility to many functional groups: alkenyl, alkynyl, chloro, and hydroxy.
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