Synthesis of 4-Aryl-2-Aminopyridine Derivatives and Related Compounds

V Pavlovic, M Petkovic, S Popovic…

Index: Pavlovic, Vladimir; Petkovic, Milos; Popovic, Stanimir; Savic, Vladimir Synthetic Communications, 2009 , vol. 39, # 23 p. 4249 - 4263

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Citation Number: 8

Abstract

Abstract A short, efficient, and high-yielding synthesis of 4-aryl-2-aminopyridine derivatives has been developed. The route employs two palladium-catalyzed processes, the Suzuki reaction and the Buchwald–Hartwig amination, as the key steps. The same approach has been used for preparation of the corresponding quinoline derivatives. In addition, a brief study of biological properties showed the anticancer potential of these compounds.