Tetrahedron: Asymmetry

Chemoenzymatic preparation of enantiopure l-benzofuranyl-and l-benzo [b] thiophenyl alanines

PV Podea, MI Toşa, C Paizs, FD Irimie

Index: Podea, Paula Veronica; Tosa, Monica Ioana; Paizs, Csaba; Irimie, Florin Dan Tetrahedron Asymmetry, 2008 , vol. 19, # 4 p. 500 - 511

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Citation Number: 32

Abstract

Both naturally occurring and unnatural α-arylalanines are frequent constituents of biological and pharmaceutical products. Several non-proteinogenic aminoacids as l-Dopa, l-homophenylalanine or d-2-naphthylalanine are already important pharmaceuticals, 1 while others such as d-phenylglycine, d-para-hydroxy-phenylglycine, and 2-thienyl-alanine are useful for the synthesis of certain drugs. 2 Many others serve as building blocks for modern drug discovery ...