Potent and selective isophthalamide S 2 hydroxyethylamine inhibitors of BACE1
…, TE Benson, MJ Bienkowski, TL Emmons…
Index: Kortum, Steven W.; Benson, Timothy E.; Bienkowski, Michael J.; Emmons, Thomas L.; Prince, D. Bryan; Paddock, Donna J.; Tomasselli, Alfredo G.; Moon, Joseph B.; LaBorde, Alice; TenBrink, Ruth E. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3378 - 3383
Full Text: HTML
Citation Number: 34
Abstract
Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D. ... The design and synthesis of a novel series of potent ...
Related Articles:
Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE
[Wu, Yong-Jin; Zhang, Yunhui; Good, Andrew C.; Burton, Catherine R.; Toyn, Jeremy H.; Albright, Charles F.; Macor, John E.; Thompson, Lorin A. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2654 - 2660]