Approach to the library of fused pyridine-4-carboxylic acids by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles

…, AS Plaskon, YV Dmytriv, OO Grygorenko…

Index: Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.; Plaskon, Andrey S.; Dmytriv, Yuri V.; Grygorenko, Oleksandr O.; Mykhailiuk, Pavel K.; Krotko, Dmitriy G.; Pushechnikov, Alexei; Tolmachev, Andrey A. Journal of Combinatorial Chemistry, 2010 , vol. 12, # 4 p. 510 - 517

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Citation Number: 11

Abstract

A library of fused pyridine-4-carboxylic acids (including pyrazolo [3, 4-b] pyridines, isoxazolo [5, 4-b] pyridines, furo [2, 3-b] pyridines, thieno [2, 3-b] pyridines, and pyrido [2, 3-d] pyrimidines) was generated by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles followed by hydrolysis of the ester. The library members were also demonstrated to undergo the standard combinatorial transformations including amide ...