… methyl (E)-4-[2-(2, 3-dihydro-3, 3-dimethyl-5-benzofuranyl)-3-hydroxy-1-propenyl] benzoate [(E)-7] as potential metabolites of selected heteroarotinoids with fused five …

…, J Klucik, S Subramanian, KD Berlin

Index: Gale, Jonathan B.; Klucik, Jozef; Subramanian, Shankar; Berlin, K. Darrell Organic Preparations and Procedures International, 2001 , vol. 33, # 5 p. 487 - 499

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Abstract

7a with HBF, gave salt 8a as yellow crystals. Cycloakylation of 8a with 2.4 equivalents of TEMPO [2, 2, 6, 6-tetramethyl-1-piperidinyoxy free radical] in freshly distilled and deoxygenated acetone gave 9a (purified by chromatography) as a yellow oil. Reductive cleavage of 9a with Zn/HOAc at 70" gave