Heterocyclic Bis-Cations as Starting Hits for Design of Inhibitors of the Bifunctional Enzyme Histidine-Containing Protein Kinase/Phosphatase from Bacillus s ubtilis

H Ramström, M Bourotte, C Philippe…

Index: Ramstroem, Helena; Bourotte, Maryline; Philippe, Claude; Schmitt, Martine; Haiech, Jacques; Bourguignon, Jean-Jacques Journal of Medicinal Chemistry, 2004 , vol. 47, # 9 p. 2264 - 2275

Full Text: HTML

Citation Number: 23

Abstract

The main mechanism of carbon catabolite repression/activation in low-guanine and low- cytosine Gram-positive bacteria seems to involve phosphorylation of HPr (histidine- containing protein) at Ser-46 by the ATP-dependent HPr kinase, which in Bacillus subtilis, Lactobacillus casei, and Staphylococcus xylosus also exhibits phosphatase activity and is thus a bifunctional enzyme (HPrK/P). Since deficiency of HPrK/P in S. xylosus, L. casei, ...