Synthesis and reactions of esters of N??hydroxyphthalimide and N??protected amino acids

GHL Nefkens, GI Tesser…

Index: Nefkens,G.H.L. et al. Recueil des Travaux Chimiques des Pays-Bas, 1962 , vol. 81, p. 683 - 690

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Citation Number: 26

Abstract

Abstract Esters can be prepared from N-hydroxyphthalimide and N-carbobenzoxy-or N- phthaloyl-amino acids using dicyclohexylcarbodi-imide as condensing agent. The compounds are suitable for the stepwise synthesis of peptides without racemization. With methanol the N-hydroxyphthalimide ester of N-phthaloylglycine can be converted into the methyl ester of N-phthaloylglycine.

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