An Efficient and Facile Synthesis of Capsaicin??Like Compounds as Agonists of the TRPV1 Receptor

VH Tran, R Kantharaj, BD Roufogalis…

Index: Tran, Van H.; Kantharaj, Ravi; Roufogalis, Basil D.; Duke, Colin C. European Journal of Organic Chemistry, 2006 , # 13 p. 2970 - 2976

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Citation Number: 6

Abstract

Abstract A new versatile synthetic route is described for the preparation of capsaicin-like molecules which contain an α-hydroxy ketone functional group mimicking the amide functional group in the capsaicin structure. The key reaction in this synthesis was the formation of α-(dimethylamino) alkanenitriles as intermediates. These nitriles were successfully prepared from both aliphatic and aromatic aldehydes by reaction with ...