Nickel??Catalyzed Cross??Coupling of Styrenyl Epoxides with Boronic Acids

DK Nielsen, AG Doyle

Index: Nielsen, Daniel K.; Doyle, Abigail G. Angewandte Chemie - International Edition, 2011 , vol. 50, # 27 p. 6056 - 6059

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Citation Number: 42

Abstract

Epoxides are invaluable substrates for complex molecule synthesis owing to their ready accessibility from alkene-and carbonyl-containing chemical feedstocks and their proclivity toward ring opening by a variety of nucleophiles.[1] Despite recent advances, reactions with carbon-centered nucleophiles are typically limited to the use of stabilized carbanions, strong organometallic reagents, or π-rich arenes.[2] The identification of a catalyst system ...