Journal of medicinal chemistry

Chemistry and pharmacology of 5-methylene-4-substituted dibenzo [. alpha., d] cycloheptenes

LG Humer, F Herr, MP Charest

Index: Humber; Herr; Charest Journal of medicinal chemistry, 1971 , vol. 14, # 10 p. 982 - 985

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Citation Number: 16

Abstract

Methods are described, utilizing the Hofmann degradation of S,~ V-diniethy1-1, 2, 3, 7, 8, 12b-hexahydrobenzo-[6, 7] cyclohepta [1, 2, 3-d, e] isoquinolinium hydroxide, which allow the synthesis of 3-methylene-10, Il-dihydro-5H-dibenzo [a, d] cycloheptenes bearing basic