The Journal of organic chemistry

Chiral Propargyl Alcohols via the Enantioselective Addition of Terminal Di-and Triynes to Aldehydes

ER Graham, RR Tykwinski

Index: Graham, Erin R.; Tykwinski, Rik R. Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6574 - 6583

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Citation Number: 21

Abstract

The enantioselective addition of di-and triynes to aldehydes is presented, including the first examples of an asymmetric triyne addition. Modification of the Carreira alkynylation protocol shows that addition of diynes and triynes to α-branched aldehydes can be complete in as