Tetrahedron: Asymmetry

Energy barrier determination of enantiomerization of chiral 3, 4-dihydro-1, 2, 4-benzothiadiazine 1, 1-dioxide type compounds by enantioselective stopped-flow HPLC

G Cannazza, D Braghiroli, P Iuliani, C Parenti

Index: Cannazza, Giuseppe; Braghiroli, Daniela; Iuliani, Piera; Parenti, Carlo Tetrahedron Asymmetry, 2006 , vol. 17, # 22 p. 3158 - 3162

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Citation Number: 14

Abstract

The synthesis and enantioseparation of chiral 3, 4-dihydro-1, 2, 4-benzothiadiazine 1, 1- dioxide derivatives are reported herein. A HPLC stopped-flow procedure was applied to the determination of rate constants and free energy barriers of enantiomerization of the compounds synthesized in the presence of achiral stationary phase. The individual enantiomers of the studied compounds were isolated in parallel by preparative HPLC on a ...