Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects

…, L Zuvela-Jelaska, R Dinallo, J Bentzien…

Index: Takahashi, Hidenori; Bekkali, Younes; Capolino, Alison J.; Gilmore, Thomas; Goldrick, Susan E.; Nelson, Richard M.; Terenzio, Donna; Wang, Ji; Zuvela-Jelaska, Ljiljana; Proudfoot, John; Nabozny, Gerald; Thomson, David Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1549 - 1552

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Citation Number: 8

Abstract

Synthesis and structure–activity relationship (SAR) of a series of nonsteroidal glucocorticoid receptor (GR) agonists are described. These compounds contain “diazaindole” moieties and display different transcriptional regulatory profiles in vitro and are considered “dissociated” ...