5-chloro-and 5, 7-dichloroisatin by chlorination of isatin with trichloroisocyanuric acid

…, BV Da Silva, F de Almeida Violante…

Index: Ribeiro; Da Silva; De Almeida Violante; Rezende; Pinto Organic Preparations and Procedures International, 2005 , vol. 37, # 3 p. 265 - 267

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Citation Number: 13

Abstract

Isatin derivatives have important biological and pharmacological properties. In particular, ketals of 5-haloisatin exhibit anticonvulsant'and ansiolitic2 activities. The classical method to prepare isatins first reported by Sandme~ er,~.~ requires several reagents and may produce hydrogen cyanide as a by-product? and the yields vary between 70 to 85%. 5-Chloroisatin and 5-bromoisatin can also be prepared from isatin using chlorine or bromine respectively ...