Potential antitumor agents. 29. Quantitative structure-activity relationships for the antileukemic bisquaternary ammonium heterocycles

WA Denny, GJ Atwell, BC Baguley…

Index: Denny,W.A. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 134 - 150

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Citation Number: 73

Abstract

Quantitative relationships between physicochemical drug properties and antileukemic (L1210) efficacy have been examined for a series of bisquaternary ammonium heterocycles employing multiple variable regression analysis. Three measures of biologic response were examined: ILS,,, the percentage increase in mean life span of leukemic animals at the LDlo dose; D,,, the drug dose necessary to provide 40% increase in life span; and CI (= LD, o/ ...

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