Copper-catalyzed oxidative coupling of carboxylic acids with formamides for the synthesis of α, β-unsaturated amides
H Li, C Pan, Y Cheng, C Zhu
Index: Li, Huamin; Pan, Changduo; Cheng, Yixiang; Zhu, Chengjian Tetrahedron Letters, 2013 , vol. 54, # 49 p. 6679 - 6681
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Citation Number: 7
Abstract
Abstract A novel and efficient protocol for the synthesis of α, β-unsaturated amides has been developed using catalytic amount of Cu (OAc) 2 and TBHP as an available oxidant. Oxidative coupling of various unsaturated carboxylic acids with N, N-disubstituted formamides was examined to furnish the desired products in good yields.
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