Tetrahedron

The total synthesis of rac-o-methyljoubertiamine

HF Strauss, A Wiechers

Index: Strauss,H.F.; Wiechers,A. Tetrahedron, 1978 , vol. 34, p. 127 - 130

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Citation Number: 8

Abstract

The Claisen-Eschenmoser [3.3] sigmatropic rearrangement1 of appropriately functionalized 3-aryl-2-cyclohexenols provides a ready synthesis of mesembrane alkaloids. 2, 3 Herein we describe the total synthesis of rac-O-methyljoubertiamine41 (1) as part of the development of a general synthetic route to these alkaloids, involving the aforementioned rearrangement as the key synthetic step.

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