N, N'-carbonyldi (2 (3H)-benzoxazolethione): New, reactive condensing agent for the synthesis of amides, esters, peptides, and polyamides.

M Ueda, N Kawaharasaki, Y Imai

Index: Ueda; Kawaharasaki; Imai Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 1 p. 85 - 89

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Citation Number: 13

Abstract

A new condensing agent, N, N′-carbonyldi [2 (3H)-benzoxazolethione](3), was readily prepared by the reaction of 2-benzoxazolethiol and trichloromethyl chloroformate in benzene. The condensing agent 3 is shown to be useful for the preparation of amides, esters, and dipeptides under mild conditions. A successful polyamide synthesis by the polycondensation of isophthalic acid with diamines using 3 is also described.