Highly efficient 1, 4-addition of 1, 3-diesters to conjugated enones by in/TMSCl

PH Lee, D Seomoon, K Lee, Y Heo

Index: Lee, Phil Ho; Seomoon, Dong; Lee, Kooyeon; Heo, Yunkiu Journal of Organic Chemistry, 2003 , vol. 68, # 6 p. 2510 - 2513

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Citation Number: 26

Abstract

The Michael reaction is one of the most efficient methods for C−C bond formation and has wide applications in organic synthesis. 1 It is usually carried out with a base as the reagent. However, it suffers from some side reactions such as autocondensations, bis-additions, rearrangements, polymerizations, and 1,2-additions in the presence of strong bases. In recent years, various reagents (LiI, DBN under high pressure, alumina, BiCl 3, and CdI 2 ) were ...