A 3, 4-Epoxypiperidine structure as a novel and simple DNA-cleavage unit
K Miyashita, M Park, S Adachi, S Seki, S Obika…
Index: Miyashita, Kazuyuki; Park, Myunji; Adachi, Sayako; Seki, Sayori; Obika, Satoshi; Imanishi, Takeshi Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1075 - 1077
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Citation Number: 15
Abstract
Based on the 4-hydroxy-1-azabicyclo [3.1. 0] hexane structure of azinomycin, a 3, 4- epoxypiperidine structure was designed as a novel and simple alkylating molecular unit, and some 3, 4-epoxypiperidine derivatives were found to show DNA-cleavage activity, the structural requirements for which were revealed.
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