Synthesis of several 1-(aminoacyl)-4-cinnamylpiperazines as potential analgetics

M Protiva, Z Kopicová, J Grimová

Index: Protiva; Kopicova; Grimova Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 636 - 643

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Abstract

Abstract A reaction of 1-cinnamylpiperazine (III) with chloroacetyl gave the chloroacetyl derivative IV which was subjected to substitution reactions with aniline, 4-phenylpiperidin-4- ol (XIa), 4-(4-fluorophenyl) piperidin-4-ol (XIb) and 4-(4-chloro-3-trifluoromethyl) piperidin-4- ol and afforded the title compounds V and VII-IX. Acylation reactions of compounds V and VII with propionyl chloride gave the propionanilide derivative VI and the 4-phenyl-4- ...