Arthrobacter sp. lipase catalyzed kinetic resolution of BINOL: The effect of substrate immobilization
…, BA Shah, N Mahajan, A Chaubey, SC Taneja
Index: Gupta, Pankaj; Rouf, Abdul; Shah, Bhahwal Ali; Mahajan, Neha; Chaubey, Asha; Taneja, Subhash Chandra Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 101, p. 35 - 39
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Abstract
Abstract (S)-1, 1′-Binaphthyl-2, 2′-diol was prepared in high optical purity (∼ 98%) via Arthrobacter sp. lipase (MTCC No. 5125) catalyzed kinetic resolution. The immobilization of the substrate on a solid inert support significantly improved the enantioselectivity factor (E) by almost sixfolds, ie from∼ 27 to> 180. The effect of acyl substituents and co-solvents were also studied.
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