Synthesis and structure–activity relationship of N-(2-arylethyl) isoquinoline derivatives as human scavenger receptor CD36 antagonists

YX Wang, L Wang, YN Xu, YH Li, JD Jiang…

Index: Wang, Yan-Xiang; Wang, Li; Xu, Yan-Ni; Li, Ying-Hong; Jiang, Jian-Dong; Si, Shu-Yi; Li, Yang-Biao; Ren, Gang; Shan, Yong-Qiang; Hong, Bin; Song, Dan-Qing European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1066 - 1073

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Citation Number: 5

Abstract

By using human scavenger receptor CD36 as the target, twenty-five N-(2-arylethyl) isoquinoline derivatives were designed, synthesized and evaluated for their antagonistic activities for CD36-oxidatively low density lipoprotein (oxLDL) binding. The primary analysis of structure–activity relationship (SAR) indicated a methoxyl at the 7-position and a hydroxyl at the 6-or 8-position could afford good activities. Among these analogs, compounds 7e ...