Enolates d'esters: V. Preparation des analogues lithiens des reactifs de reformatsky a partir des esters α, α-dichlores et α-monohalogenes. Reactivite

J Villieras, P Perriot, M Bourgain, JF Normant

Index: Villieras,J. et al. Journal of Organometallic Chemistry, 1975 , vol. 102, p. 129 - 140

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Citation Number: 16

Abstract

Abstract The reaction of lithium on α, α-dichloroesters and α, α-disubstituted α- monohaloesters in THF at 0 to− 5 C leads to the formation of the lithioanalogs of the corresponding Reformatsky reagents in good yields (80–90%). Their reactivity has been tested toward various electrophiles. It illustrates the wide scope of synthetic utility of these reagents (alkylation with primary and secondary alkyl bromides, hydroxy alkylation, ...