The Synthesis of 3-Alkyl-4-methylquinolines1

AL Searles, HG Lindwall

Index: Searles; Lindwall Journal of the American Chemical Society, 1946 , vol. 68, p. 988

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Citation Number: 15

Abstract

The cyclization of acetoacetanilide (I, R= H) was first carried out by Knorr, 2 who subsequently demonstrateda that it was a reaction generally applicable to acetoacetylated aryl amines possessing a vacant ortho position. Although the aryl portion of the molecule has been varied widely, a survey of the literature shows that few attempts have been made to prepare acetoacetanilides carrying alkyl groups in the alpha position. Accordingly, ...