(5-Amino-1, 3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl) methanones. A series of novel potential antipsychotic agents
…, LL Coughenour, DA Downs, TG Heffner…
Index: Wise; Butler; DeWald; Lustgarten; Coughenour; Downs; Heffner; Pugsley Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1628 - 1637
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Citation Number: 4
Abstract
18 1 be obtained by this sequence. 6 A somewhat better route described recently by DeWald (Scheme IIB) involved bromination of 4, followed by lithium exchange and reaction of the lithium compound with methyl 2-fluorobenzoate to give 5, which was hydrolyzed to l. 9 In a US patent Swett and associates described the reaction of l, 3-dimethyl-lli-pyrazold- amine 131 with the Vilsmeier complex to give carboxaldehyde 14 in which the 5-amino ...
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