Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell

…, T Ng, MJ Lawrence, SL Hart, HC Hailes…

Index: Hurley, Christopher A.; Wong, John B.; Ho, Jimmy; Writer, Michele; Irvine, Scott A.; Lawrence, M. Jayne; Hart, Stephen L.; Tabor, Alethea B.; Hailes, Helen C. Organic and Biomolecular Chemistry, 2008 , vol. 6, # 14 p. 2554 - 2559

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Citation Number: 34

Abstract

Recent research in the field of nonviral gene delivery vectors has focused on preparing nanoparticles that are stabilized by the incorporation of a PEG coating and where one of the vector components is also cleavable. Here, we describe the synthesis, formulation, transfection properties, and biophysical studies of a PEG-stabilized ternary lipopolyplex vector in which, for the first time, both the lipid and peptide components are designed to be ...