Helvetica Chimica Acta

The 't??Amino Effect'of ortho??Nitroso Amines. Synthesis of 2, 6??Diaminoadenine Derivatives from 6??(Dialkylamino)??5??nitrosopyrimidines

M del Carmen Ruiz Ruiz, A Vasella

Index: Del Carmen Ruiz, Maria; Vasella, Andrea Helvetica Chimica Acta, 2011 , vol. 94, # 5 p. 785 - 800

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Citation Number: 9

Abstract

Abstract The 't-amino effect'of amino-nitroso compounds was documented by preparing the (dialkylamino)-nitroso pyrimidines 4–18, and cyclising them under thermal conditions in high yields to the purine derivatives 19–32. The reactivity of the amino-nitroso-pyrimidines, particularly of 17 derived from diethyl iminodiacetate, and of 19, derived from 1- phenylimidazolidine, correlates with the stability of the intermediate azomethine ylide. ...

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