Discovery of a Novel, Efficient, and Scalable Route to Bendamustine Hydrochloride: The API in Treanda

J Chen, K Przyuski, R Roemmele…

Index: Davies, Lawrence C.; Friedlos, Frank; Hedley, Douglas; Martin, Jan; Ogilvie, Lesley M.; Scanlon, Ian J.; Springer, Caroline J. Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5321 - 5328

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Citation Number: 9

Abstract

... Dev. All Publications/Website. Select a Journal or Book ... (3) Several purification steps are required to provide the final product in sufficient purity for use as a pharmaceutical API. ... Table 1. Effect of Solvent on the Acylation of 13. run, solvent, time (h), temp (°C), HPLC (A%) 13. ...