Chemistry Letters

Reaction of spiro (cyclohexane-1, 3'-3H-indole) with Grignard reagents in the presence of cuprous chloride.

G Rodriguez, Y Benito, F Temprano

Index: Rodriguez, Gonzalo; Benito, Yolanda; Temprano, Fernando Chemistry Letters, 1985 , p. 427 - 428

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Citation Number: 4

Abstract

Attack of MeMgl and PhMgBr in toluene on spiro [cyclohexane-1, 3′-3H-indole](1) in the presence of Cu 2-Cl 2 gives 2′-substituted spiro [cyclohexane-1, 3′-indolines] in quantitative yields. Also, attack of PhCH 2 CH 2 MgBr on 1 in the presence of Cu 2 Cl 2 afforded 2′-phenethyl, 2′-H and 2′-benzyl (or 2′-p-xylyl) derivatives in toluene (or p- xylene) as solvent.